Jianlin Meng, MD, PhD
Phone number：+8618256921822
E-mail：mengjialin@ahmu.edu.cn
Institute website：https://genitourinaryhealth.ayfy.com/info/1055/1115.htm
Research and Employment
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2016.07-2017.08 State Key Laboratory of Molecular Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Joint-training Program
2018.04-2020.07 George H. Whipple Laboratory for Cancer Research, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, USA
Visiting Scholar
2021.07 to now The First Affiliated Hospital of Anhui Medical University, Anhui, China
Associated Professor, Resident Doctor
Funding
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1.Natural Science Foundation of China, 82200860，High-fat diet promotes Th17 cell differentiation and aggravates CNP through DJ-1/STAT3 axis, 2023-01 to 2025-12
2.Natural Science Foundation of Anhui Province, 2208085QH239,The IGF1/IGF1R axis mediates the occurrence of chronic nonbacterial prostatitis by activating the PKC-β pathway and promoting Th17 differentiation, 2022-01 to 2023-12
3. Natural Science Research in Colleges and Universities of Anhui province, 2022AH051133, Lipoprotein(a) regulates the differentiation of M1 macrophages and promotes the progress of chronic nonbacterial prostatitis, 2023-01 to 2024.12.
Research Biography
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Major in clinical and basic research on prostate diseases, and has a certain research foundation in the immune microenvironment affecting the occurrence of chronic prostatitis and prostate cancer.
In the research ofchronic non-bacterial prostatitis (CNP),①Reported the rate of CNP in Anhui men is 51.65%, suggesting that CNP occurs widely in young, middle-aged and elderly men;②Revealed the history of systemic chronic infection and frequent sexual behavior are risk factors for the occurrence of CNP in young college students;③Single-cell sequencing confirmed that the proportion of pro-inflammatory CD4+ effector T cells such as Th1, Th17, and Th22 in the peripheral blood of CNP patients was significantly increased;④Validated that HA/ CD44 axis regulates cell cycle and promotes Th1 cell differentiation;⑤Reported that enhanced autophagy can promote the increase of anti-inflammatory Treg cells and alleviate the symptoms of CNP.
In the research ofprostate cancer (PCa),①Revealed that the increased proportion of M2 macrophages infiltration was closely related to the poor prognosis of prostate adenocarcinoma patients;②Found that M2 macrophages can transmit miRNA-320b/ATP1B1/ PI3K /AKT pathway, which regulates the sensitivity of prostate cancer cells to enzalutamide treatment;③Proposed that prostate cancer patients can be divided into immune-activating subtypes, immunosuppressive subtypes, and non-immune subtypes, and the immune-activating subtypes have a longer Relapse-free survival and more likely to benefit from anti-PD-1/PD-L1 immunotherapy;④Developed the R package "MOVICS" for multi-omics composite analysis of diseases, combining transcriptome, methylation, mutation, etc. Dimensional data identifies molecular subtypes of prostate cancer, providing new strategies for patient selection for clinical androgen deprivation therapy.
All published articles have been cited 719 times in total, with an H-index of 16.
Review experience
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Major in clinical and basic Up to now, I already completed 257 times of peer review, and also recorded in the Web of Science (Publons).
Publication list
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1.Meng Jialin#,Ge Qintao#, Li Jiawei#, Lu Xiaofan, Chen Yonghao, Wang Haitao, Zhang Meng, Du Juan, Zhang Li, Hao Zongyao, Liang Chaozhao. Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis. Journal of Infection. 2022 Jun;84(6):834-872. doi: 10.1016/j.jinf.2022.03.020.(IF=38.637, JCR Q1)
2.Meng Jialin#, Jin Chen#, Li Jiawei, Zhang Song, Zhang Meng, Hao Zongyao, Chen Xianguo*, Zhang Li*, Liang Chaozhao*. Metabolomics analysis reveals the differential metabolites and establishes the therapeutic effect prediction nomogram among CP/CPPS patients who respond or do not respond to LiST. 2022 July26;13:953403. doi:10.3389/fimmu.2022.953403(IF= 8.786, JCR Q1)
3. Chen Jing#,Meng Jialin#(co-first author), Li Xiaoling, Li Xiao, Liu Yi, Jin Chen, Zhang Li, Hao Zongyao, Chen Xianguo*, Zhang meng*, Liang Chaozhao*. HA/CD44 Regulates the T Helper 1 Cells Differentiation by Activating Annexin A1/Akt/mTOR Signaling to Drive the Pathogenesis of EAP. Frontiers in Immunology. 2022 May 26;13:875412. doi:10.3389/fimmu.2022.875412(IF= 8.786, JCR Q1)
4.Meng Jialin#,Lu Xiaofan#, Jin Chen#, Zhou Yujie, Ge Qintao, Zhou Jun, Hao Zongyao, Yan Fangrong*, Zhang Meng*, Liang Chaozhao*. Integrated Multi-Omics Data Reveals the Molecular Subtypes and Guides the Androgen Receptor Signaling Inhibitor Treatment of Prostate Cancer.Clinical and Translational Medicine, 2021, 11(12):e655. doi: 10.1002/ctm2.655.(IF=8.554, JCR Q1)
5.Meng Jialin#, Zhou Yujie, Lu Xiaofan, Bian Zichen, Chen Yiding, Zhou Jun, Zhang Li, Hao Zongyao, Zhang Meng*, Liang Chaozhao*. Immune Response Drives Outcomes in Prostate Cancer: Implications for Immunotherapy. [J] Molecular Oncology, 2021, 15(5):1358-1375. doi: 10.1002/1878-0261.12887. (IF=7.449, JCR Q1).
6. Meng Zhang#, Chen Jin#, Yang Ding#, Yuqing Tao, Yulin Zhang, Ziyue Fu, Tao Zhou, Li Zhang, Zhengyao Song, Zongyao Hao,Jialin Meng* (Co-corresponding author)and Chaozhao Liang*, Higher Intake of Fat, Vitamin E-(β+γ), Magnesium, Sodium, and Copper Increases the Susceptibility to Prostatitis-like Symptoms: Evidence from a Chinese Adult Cohort. [J] Nutrients, 2022, 14(18), 3675. doi: 10.3390/nu14183675.(IF=6.706, JCR Q1).
7.Meng Jialin#, Guan Yu#, Wang Bijun, Chen Lei, Chen Junyi, Zhang Meng, Liang Chaozhao. Risk subtyping and prognostic assessment of prostate cancer based on consensus genes. Communications Biology. 2022 Mar 15;5(1):233. doi: 10.1038/s42003-022-03164-8.(IF=6.548, JCR Q1).
8.Meng Jialin#,Lu Xiaofan#, Zhou Yujie#, Zhang Meng, Ge Qintao, Zhou Jun, Hao Zongyao, Gao Shenglin*, Yan Fangrong*, Liang Chaozhao*. Tumor immune microenvironment-based classifications of bladder cancer for enhancing the response rate of immunotherapy. [J] Molecular Therapy-Oncolytics, 2021, 20:410-421. doi: 10.1016/j.omto.2021.02.001.(IF=6.311, JCR Q1).
9.Jialin Meng#, Yonghao Chen#, Xiaofan Lu#, Qintao Ge, Feixiang Yang, Suwen Bai, Chaozhao Liang*, Juan Du*, Macrophages and monocytes mediated activation of oxidative phosphorylation implicated the prognosis and clinical therapeutic strategy of Wilms tumour. [J] Computational and Structural Biotechnology Journal, 2022, https://doi.org/10.1016/j.csbj.2022.06.052.(IF=6.155, JCR Q1).
